This research aims to explore the role and typology of innovation intermediation in the context of technological regime and service pattern, especially focusing on the difference of functional roles in each category. To answer the research question concerning innovation intermediaries, the research consists of several parts utilizing both qualitative and quantitative approaches of factor analysis, cluster analysis, and expert interview, respectively. In light of this research design, the results of this research are therefore threefold, namely, constructing a framework of technological regime, providing a typology and business model analysis of innovation intermediaries in terms of technological regime and service pattern, and identifying the specialized roles of public intermediary, private intermediary and TLOs in universities in this typology.