In 2009, a project of monitoring and evaluation of China's Popularization of Science and Technology Infrastructures (PSTI) development was conducted. The index system for China's PSTI development was studied and established. By using these evaluation indexes, monitoring and evaluation of China's PSTI was carried out and abundant detailed data were collected. Through the analysis of the monitoring data, a comprehensive understanding of China's PSTI development status was obtained, the reason was analyzed, and the trend of China's PSTI development was forecasted. These results can not only lay a solid foundation for annual monitoring and evaluation project of China's PSTI in the future, but also provide a policy-making support for accelerating China's PSTI construction. The authors believe this research will be a precious reference for other countries and regions on PSTI development.